奥利维亚巴恩斯is a Senior Research Nurse at Sherbourne Medical Centre in Leamington Spa. In this series of weekly posts she discusses how COVID-19 is impacting the clinical trials she is working on, as well as her work on studies in response to the virus.在这里阅读以前的条目。

Last week we sent two thousand text messages for the anti-malarial drug COVID-19 study – it is a 50/50 randomized split between those taking the drug and self-testing, and those just self-testing. Within a day we had two ladies who contacted the help desk and were eligible. One was allocated to the drug and one just to swabbing. We actually dropped the drugs and kits off to them because we were be able to do that on our way home, though the NIHR are co-ordinating courier services if we need them. It is always the first patients in any study when you find glitches, but all went reasonably well. It will be interesting to see the result, which will take about a week to come back.

And on the self-testing study we have had three patients and the first two came back negative. However, we haven't had any recruits this week so far for either study. I know hindsight is a wonderful thing, but it would have been good if we could have coordinated with 111 services, as that is where people are being told to go in the first instance if they suspect they have COVID-19. However, they were just so busy, I think it would have been difficult.

这study that we have had the best results on is one on serology testing, from the RCGP via Oxford University. It is for patients who had to be attending the surgery for a blood test – we couldn't approach anybody else other than people already having booked for a blood test here at the surgery. They have been given a one page patient information sheet and asked if they mind having an extra tube of blood taken for this research. The patients won’t get results and we won’t get results – it is purely to look at background immunity in the general population.

前26名患者进入手术，25名同意参加，我不得不订购另外50个套件。如果没有我们的手术HCA的帮助，那么就无法看到所有患者的血液测试。除了她自己的工作之外，她还帮助了这个项目，采取了口头同意，标志着样品，甚至在她的转变结束时将套件带到邮局。

人们非常乐意帮助NHS并且是相当的利他主义 - 这是一件可爱的东西。我在正常的工作日看到它 - 我们在舍本斯班省做了很多研究，我们的患者非常了解这一点 - 通常我们甚至在II期或早期III期研究中没有出现志愿者的问题。

我也不得不在Covid-19周围做一些教育，所以我可以帮助患者背景信息。这世界卫生组织有一个非常好的页面显示血清学测试之间的差异 - 他们正在尝试做什么以及可用的测试。